Immunodominance Hierarchies and Gender Bias in Direct TCD8-Cell Alloreactivity

A predictive model of immunodominance hierarchies in influenza infection

— We present a model to account for the cellular phenomenon of immunodominance—the differential expansion of antigen-specific populations in response to infection. Specifically, our model addresses CD8+ T cell immunodominance in influenza infection. This model is based on experimental data and is responsive to two main parameters—the epitope density of antigen presented on the cell surface of i...

Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.

The action of TdT on mouse TCR genes accounts for approximately 90% of T cell repertoire diversity. We report that in TdT-/- mice, total T(CD8+) responses to influenza and vaccinia viruses are reduced by approximately 30% relative to wild-type mice. We find that T(CD8+) responses to three subdominant influenza virus determinants are reduced to background values in TdT-/- mice while responses to...

CD8+ TCR Bias and Immunodominance in HIV-1 Infection.

Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen. In the case of CD8(+) T cells, these constrained epitope-targeting patterns are linked to HLA class I expression and determine disease progression. Despite the biological importance of these predetermined response hierarchies, little is kn...

Mice Alloreactivity During Allograft Rejection in Contributions of Direct and Indirect T Cell

Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice.

The immune response to transplanted allogeneic tissues is mediated by T cells that recognize donor histocompatibility Ags either via direct (donor MHC and peptides) or indirect (recipient MHC and donor-derived peptides) allorecognition pathways. The relative contribution of each of these pathways to allograft rejection remains largely unknown. To address this, we used an enzyme-linked immunospo...